Delays could be caused on the seafront road at Ovingdean as the council resurfaces a worn-out section of the A259.
The road’s surface is cracking and worn. Officials say it cannot be left much longer without deteriorating seriously.
The dual carriageway will be closed, one side at a time, between Monday September 7 and Saturday September 12, inclusive. A contraflow will be in operation so traffic flow will always be maintained in each direction.
However drivers are advised to find an alternative route if they can.
The junction with Greenways, at the Ovingdean Roundabout, will be closed throughout the works.
Works will extend over a section roughly 200 metres west of the roundabout to 100 metres east.
A special shuttle bus will be provided to pick people up from around Ovingdean village to take them to join the main Big Lemon bus service at Falmer Road.
Acting council chief executive Geoff Raw said: “People are rightly concerned about potholed roads – and unfortunately this is what it takes to prevent them. We’ll be doing our best to minimise disruption and thank people in advance for their patience.”
From the Monday to the Wednesday, the eastbound carriageway will be dug out to a depth of 100mm and laid with new asphalt. Then the westbound carriageway will get the same treatment between Thursday and Saturday.